Glo SB Sachet
Composition
| Lyophilized Saccharomyces boulardii CNCM I-3799 : | 282.5 mg (eq. to 250 mg of Yeast) |
| Excipients: | q.s. |
Pharmacodynamics
Consistent evidences have shown the potential effect of some specific probiotic strain, such as Saccharomyces cerevisiae var. Boulardii (S.boulardii), in promoting recovery from acute diarrhoea. S.boulardii is today one of the most documented nutritional interventions in reducing diarrhoea duration in adults and children.
We are using Lynside® Pro SCB Saccharomyces boulardii CNCM I-3799 from Gnosis by Lesaffre in Glo SB. Lynside® Pro SCB Saccharomyces boulardii CNCM I-3799 has more than 75 clinical studies conducted in over 100 countries.
Lynside Pro SCB is more resistant to gastric acid and bile salts, making it more effective in the gut. It binds to pathogens and creates gut detoxification by rapid excretion of these pathogens. Advantages:
– Does not inter-act with antibiotic treatment
– No risk of antibiotic resistance gene transfer
– Long shelf life due to a unique drying process
– Very stable at ambient temperatures
– Lactose and Gluten free, a non-GMO
Lynside® Pro SCB is a probiotic yeast, well documented by scientific papers. The strain used by Lesaffre, Saccharomyces cerevisiae var. boulardii CNCM I-3799, helps intestinal comfort and contributes to maintain the intestinal flora.
Lynside® Pro SCB Saccharomyces boulardii CNCM I-3799 acts by inhibiting the pathogenic effects of certain micro-organism and/or their toxins, especially Clostridium difficile, the principle causative organism in antibiotic-associated diarrhoea, and Vibrio cholerae, typical of the toxin-producing bacterium responsible for secretory diarrhoea.
Lynside® Pro SCB Saccharomyces boulardii CNCM I-3799 exerts a trophic and immunostimulant effects on the intestinal tract involving notable and significant increase in the total and specific activity of the intestinal disaccharidases (sucrase, maltase and lactase), and marked increase in secretory IgA concentrations in the intestinal fluid.
With its proven antibacterial and antitoxin effects, S. boulardii helps to reduce diarrhoea through multiple mechanisms including the binding of intestinal pathogens and their elimination.
THE POWER OF YEAST
- Lynside® Pro SCB, THE MOST STABLE boulardii IN THE MARKET
- Natural bioactive ingredient
- No antibiotic susceptibility with no side effects
- No colonization effects
- No risk of habituation
- No risk of transfer of resistance genes to bacteria
- No pro-inflammatory effect
- Resistance to gastric acid and bile salts
Lynside® Pro SCB, with its fine-tuned drying process from Lesaffre expertise guarantees:
- A longer probiotic shelf-life 5 years
- A superior stability in various packaging
Pharmacokinetics
Lynside® Pro SCB Saccharomyces boulardii CNCM I-3799, after repeated oral doses, transits in the digestive tract without colonizing it, rapidly attaining significant intestinal concentrations, which are maintained at a constant level throughout the administration period. The cells are spread throughout the small and large intestines, creating a barrier in the gut against bad bacteria. Saccharomyces boulardii is not present in the stools 2–5 days after discontinuation of treatment.
Indications
- Treatment of acute infectious diarrhoea in adults and children
- Prevention and treatment of antibiotics-associated colitis and diarrhoea
- As an addition to vancomycin/metronidazole-treatment to prevent the recurrence of Clostridium difficile diseases
Dosage and Administration
One to two sachets to be given twice daily or as directed by the physician
Glo SB powder should be administered orally, directly or mixed with water (5-10 ml) or a beverage, or in a baby’s feeding bottle. The contents of the sachet should not be mixed in very cold or hot liquids or food.
Contraindications
In patients with a known hypersensitivity to any of the ingredients of the formulation or yeast allergy.
Warnings and Precautions
General
Glo SB powder contains living cells and, therefore, it should not be mixed with very hot (over 50?C), iced or alcoholic drinks or food.
The treatment with Saccharomyces boulardii does not replace rehydration. The patient should be appropriately rehydrated based on the severity of diarrhoea, age and the state of health of the patient.
Drug Interactions
Glo SB powder should not be administered with systemic or oral antifungal drugs, because of the fungal nature of this formulation.
Pregnancy
The safety and efficacy have not been established in pregnant women.
Lactation
The safety and efficacy have not been established in nursing mothers.
Storage and Handling Instructions
Glo SB powder should be stored below 30°C and protected from light.
Packaging Information
Glo SB powder is available as 0.84 g sachet
References
Infection and Immunity, Vol. 64, No 12: 5225-5232.
- Lynside, Gnosis and Lesaffre are trademarks of respective companies
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