Happreg Tablets
Composition
Each Tablet contains:
| Methylcobalamin: | 1500 mcg |
| L-Methylfolate: | 1 mg |
| Pyridoxal 5'-phosphate: | 0.5 mg |
Pharmocology
Mechanism of Action
L-methylfolate is the primary biologically active isomer of folic acid and the primary form of folate in circulation. Folic acid is a precursor of tetrahydrofolic acid, which is involved as a cofactor for transformylation reactions, these reactions are involved in the biosynthesis of thymidylates and purines of nucleic acids
Methylcobalamin
- Enhances synthesis proteins in nerve cells
- Promotes myelinization
- Axonal regeneration
- Helps in generation of enzyme methionine synthase -regeneration of methionine from homocysteine.
- Restores diminished neurotransmitter (Acetylcholine) levels.
Methylcobalamin as a coenzyme of methionine synthetase, plays an important role in transmethylation in the synthesis of methionine from homocysteine.
Methylcobalamin is well transported to nerve cell organelles, and promotes nucleic acid and protein synthesis.
Pyridoxal Phosphate is a coenzyme of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. Pyridoxal phosphate acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids.
Pharmacokinetics
L-methylfolate is a water-soluble molecule which is primarily excreted via the kidneys.
The mean elimination half-life is approximately 3 hours after 5mg of oral L-methylfolate, administered daily for 7 days. Red blood cells (RBCs) appear to be the storage depot for folate, as RBC levels remain elevated for periods in excess of 40 days following discontinuation of supplementation. Plasma protein binding studies showed that L-methylfolate is 56% bound to plasma proteins.
Methylcobalamin bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and is then actively absorbed from the gastrointestinal tract.
Methylcobalamin is extensively bound to specific plasma proteins called transcobalamins; transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues. Methylcobalamin is stored in the liver, excreted in the bile, and undergoes extensive enterohepatic recycling; part of a dose is excreted in the urine, most of it in the first 8 hours; urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means. Methylcobalamin diffuses across the placenta and also appears in breast milk.
Pyridoxal-5′-phosphate (PLP) is the active form of vitamin B6. PLP is readily absorbed by the intestine by a process which is preceded by dephosphorylation to form pyridoxal.
Indications
- PIH
- Preeclampsia
- IUGR
- NTDs
- Recurrent abortion
Contradictions
Patients with Hypersensitivity to components of the formulation.
Dosage
Happreg Tablets – One tablet daily
Presentation
Happreg Tablets – Strip of 10 Tablets
Store at controlled room temperature 15⁰C to 30⁰C.
Protect from heat, light and moisture.
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